A source for NBC News has confirmed that Ted Cruz will pick former HP CEO Carly Fiorina as his running mate should he get the nomination. 

The move by Cruz comes as an attempt to regain momentum after suffering a crushing blow from opponent Donald Trump Tuesday night, losing five northeastern primaries to the real-estate mogul.

Fiorina will appear alongside Cruz at a campaign rally in Indianapolis Wednesday afternoon to make the announcement. 

Though unsuccessful in her presidential bid, Fiorina has proven to be a fierce debater and a strong critic of Donald Trump, especially after the GOP frontrunner made disparaging comments about her face last year.

She has also been a strident defender of Ted Cruz against attacks. When Cruz faced allegations of past adultery, Fiorina jumped to his defense, putting the heat on Trump by calling him  "a serial philanderer."

At the time, Fiorina told reporters she felt that Cruz faced "absurd" questions that she was prepared to fight back against.

"Let's face it - sometimes the questions that the media asks are absurd, and as you have come to know me on the campaign trail, I don't shy away from taking it on," Fiorina told reporters. "So there are times when I think someone other than Ted can say things that he can't say. And in that particular case, it was just an outrageous, absurd question."

The last presidential candidate to announce his running-mate before a potential open convention was Ronald Reagan in 1976, tapping Sen. Richard Schweiker for his VP.

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